In adult [16] and pediatric [17] acute myelocytic leukemia patients with t(11;12)(p15;q13), a fusion of exon 2 of HOXC11 and exon 12 of NUP98, and chromosomal break of exon 1 of HOXC11 contribute to acute myelocytic leukemia, respectively. This evidence concerns the gene HOXC11 and acute myeloid leukemia.