In the immortalized cell lines (HEC-1/KLE) and other primary endometrial carcinoma cells (“phEC-2/phEC-3”), treatment with IMT1 (0.5 μM) activated Caspase-3 (Fig. 2F) and increased nuclear TUNEL-positive staining (Fig. 2G), supporting apoptosis activation. The gene discussed is CASP3; the disease is endometrial carcinoma.