At that point, laboratory analysis revealed renal insufficiency (creatinine 3.1 U/dL, urea 82 U/dL); increased liver enzyme levels (AST 214 U/L, ALT 95 U/L), increased serum (6.7 mg/dL) and direct (3.12 mg/dL) bilirubin; and increased INR 1.88. The gene discussed is GPT; the disease is Renal insufficiency.