Considering the Brighton Collaboration criteria for case definition (3), 4 patients (cases 1–4) met >3 major criteria: hepatic abnormalities (total bilirubin >1.5 times the upper limit of normal [ULN] or ALT or AST >3 times ULN), renal abnormalities (creatinine >1.5 times ULN), musculoskeletal abnormalities (CPK >5 times ULN), respiratory abnormalities (oxygen saturation <88% on room air or need for mechanical ventilation), platelet count <100,000/μL, and coagulopathy (INR>1.5). Here, GPT is linked to blood coagulation disease.