PRKN and Alzheimer disease: The activity of Parkin in the clearance of ubiquitinated Aβ in AD models involves beclin-dependent autophagy.93,94 A further link with copper homeostasis was thus revealed by the recent finding that intracellular copper can stimulate autophagy in lung adenocarcinoma cells by enhancing activity of the autophagic kinases ULK1 and ULK295 through direct binding of copper to these proteins.