For example, Nair et al. showed that acute 17β-estradiol-dependent activation of enhancers in the MCF7 breast cancer cells is featured with the assembly of an enhancer RNA (eRNA)–dependent ribonucleoprotein (eRNP) complex that displays properties of phase-separated condensates; such condensates are composed of a so-called ‘MegaTrans’ complex formed by a set of TFs and coactivators (such as ER-alpha, FOXA1, GATA3, p300, and mediator) [127], eRNA, and condensin [128]. Here, ESR1 is linked to breast cancer.