Specifically, new DNA loops are formed with their anchors associated with binding of EWS/FLI and not CTCF [125]; in addition, EWS/FLI binds to the GGAA-rich motifs in the genome of Ewing’s sarcoma, leading to new enhancer formation, A-type compartmentalization, and target gene upregulation [125]. The gene discussed is EWSR1; the disease is Ewing sarcoma.