The European League against Rheumatism Sjögren’s syndrome disease activity index (ESSDAI) was significantly decreased after HCQ treatment in both the high-LAMP3 group (5.0 ± 2.9 to 1.4 ± 2.2, P < 0.05) and normal-LAMP3 group (5.9 ± 3.4 to 2.2 ± 3.2, P < 0.01). Here, LAMP3 is linked to Sjogren syndrome.