Here we report the generation and characterization of a porcine model for CD carrying a 93-bp deletion in the 3ʹ-untranslated region [UTR] of TNF [TNFα], which deleted the transcript-destabilizing AU-rich element [ARE] and a constitutive decay element [CDE] similar to the TNFΔARE mouse model. The gene discussed is TNF; the disease is Cowden disease.