CD4 and neoplasm: Consequently, the T cell–unfavorable tumor microenvironment in liver metastasis (4) was reshaped, as evidenced by abundant intratumoral infiltration of CD4+ and CD8+ T cells in E. coli–sgMafb/Maf–treated mice compared with E. coli–vector–treated mice (Figure 7, D and E, and Supplemental Figure 15, A and B).