Although peritumoral KCs were rarely labeled with propidium iodide (PI) (Supplemental Figure 10C), tumor-enriched liver tissues had a higher proportion of annexin V+KCs than tumor-scarce liver tissues (Supplemental Figure 10, D–F), implying that apoptosis rather than necroptosis could play at least a partial role in tumor-induced KC loss. This evidence concerns the gene ANXA5 and neoplasm.