Notably, pretreatment of WT DCs with 2-DG reduced the numbers of tumor-infiltrating cGAMP-stimulated DCs, CD4+ T cells, and CD8+ T cells and decreased the frequencies of tumor-infiltrating IFN-γ–producing and granzyme B–producing CD4+ and CD8+ T cells (Figure 4, D–F). This evidence concerns the gene IFNG and neoplasm.