CD4 and neoplasm: In contrast, mice injected with STING-deficient DCs pretreated with or without 2-DG displayed no apparent differences in the numbers of tumor-infiltrating cGAMP-stimulated DCs, CD4+ T cells, and CD8+ T cells or the frequencies of tumor-infiltrating IFN-γ–producing and granzyme B–producing CD4+ and CD8+ T cells (Figure 4, D–F).