Indeed, T2D-associated variants are enriched at LSD1-bound sites to a greater extent than at LSD1-unbound sites (P = 0.0056 by 2-tailed Welch’s t test; Figure 6C and Supplemental Figure 8I), indicating LSD1-bound active chromatin is specifically enriched for T2D-associated variants beyond what is expected for islet active chromatin in general. Here, KDM1A is linked to type 2 diabetes mellitus.