APAF1 and non-small cell lung carcinoma: By inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C (PKC-), and sarcoma viral oncogene homolog, they demonstrated that these miRNAs played significant roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo (SCR, non-receptor cytoplasmic tyrosine kinase).