Although it has been established that the MET oncogene has a role in both de novo and acquired resistance of non-small cell lung malignancies to tyrosine kinase inhibitors (TKIs), the specific mechanism by which MET overexpression results in TKI-resistant NSCLC is still unknown (Bisagni et al. 2018). The gene discussed is MET; the disease is non-small cell lung carcinoma.