Consistent with the in vitro results, BCAA significantly inhibited the growth of NSCLC (Fig. 1g, P value = 0.0106), colon cancer (Fig. 1h, P value = 0.0498), and breast cancer (Fig. 1i, P value = 0.0358) and reduced the tumor weight compared to the control group. Here, ARID4B is linked to malignant colon neoplasm.