Analysis of sequencing data from clinical NSCLC samples in the TCGA database showed that the expression of IARS1 (R = 0.42, p < 0.01) and IARS2 (R = 0.38, p < 0.01) both showed a potential positive correlation with PTEN expression (Fig. 5c & Supplementary Fig. 3a–c). This evidence concerns the gene IARS1 and non-small cell lung carcinoma.