Thus, this study was performed in patients with T2DM and biopsy-proven DKD 1) to explore the relationship between NT-proBNP concentration and pathological changes and 2) to explore whether NT-proBNP as a biomarker could predict kidney prognosis in patients with T2DM and biopsy-proven DKD. Here, NPPB is linked to type 2 diabetes mellitus.