CD44 and non-small cell lung carcinoma: The response to prostaglandin is also a classical inflammatory response pathway, which includes multiple inflammatory cytokines (prostaglandin D2, prostaglandin E2, and thromboxane A2),[35] which are closely associated with lung cancer and asthma.[36] GO enrichment analysis associated with CC suggested that proteoglycan binding was most significant, and previous studies have shown that proteoglycan binding to CD44 has the potential to promote NSCLC cell migration.[37] Furthermore, KEGG enrichment analysis showed that the sphingolipid signaling pathway was the most significant pathway.