CCNB2, a member of the cyclin family, plays a major role in G2/M transformation and is upregulated in many cancers.[12] CCNB2 is highly expressed in glioma and is associated with poor prognosis, while decreased CCNB2 expression inhibits the invasion and metastasis of cancer.[13] However, the relationship between CCNB2 and oral and bladder cancers remains unclear. The gene discussed is CCNB2; the disease is central nervous system cancer.