TP53 and pancreatic adenocarcinoma: PRMT5 is another known regulator of oncogenic development through its ability to regulate p53 pathway signaling and to drive the proliferative, invasive, and metastatic activity of tumor cells.[20] SF3B2 has been linked to a range of cancers such as pancreatic adenocarcinoma, renal cell carcinoma, and papillary carcinoma.