FAM66C and central nervous system cancer: For example, CRNDE is upregulated in gliomas, and CRNDE overexpression predicts high malignant level and poor clinical prognosis of glioma.[41] FAM66C is downregulated in glioma tissue, and its deletion can significantly promote cell proliferation and migration, which is associated with the regulation of miRNA/LATS1 signaling pathway.[42] HOTAIRM1, as an oncogenic lncRNA in gliomas, is linked to a variety of malignant progression of gliomas.[43,44] Based on function enrichment analyses, DEGs were observed to be closely linked to various immune-related functions and pathways.