NT5DC (5′-Nucleotidase domain containing) family is an extremely well-conserved 5′-nucleotidase, which have a haloacid dehalogenase motif in their N-termini, including NT5C2, NT5DC1, NT5DC2, NT5DC3, and NT5DC4.[5] NT5DC family members participated in hereditary spastic paraplegia, mental disorders, and metabolic disorders.[6] Recently, multiple studies have linked NT5DC family members to tumor progression. This evidence concerns the gene NT5DC2 and neoplasm.