Therefore, one of the pathways associated with apoptosis factors attended to be targeted for cancer therapy is the anti-apoptotic B-cell lymphoma-2 (Bcl-2) family of proteins, including Bcl-w and Bcl-xL Bfl1/A-1, Bcl-2, Mcl-1, and Bcl-B [36]. The gene discussed is BCL2; the disease is cancer.