The degree values of 15 targets, including AKT1, CASP3, CXCL8, EGFR, ESR1, FOS, IL-1β, IL-6, JUN, MMP9, PPARG, PTGS2, TNF, TP53, and VEGFA were high, and it was speculated that these targets may be key targets of TBFS in the treatment of COPD. This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.