The degree values of 15 targets, including AKT1, CASP3, CXCL8, EGFR, ESR1, FOS, IL-1β, IL-6, JUN, MMP9, PPARG, PTGS2, TNF, TP53, and VEGFA were high, and it was speculated that these targets may be key targets of TBFS in the treatment of COPD. Here, ESR1 is linked to chronic obstructive pulmonary disease.