The degree values of 15 targets, including AKT1, CASP3, CXCL8, EGFR, ESR1, FOS, IL-1β, IL-6, JUN, MMP9, PPARG, PTGS2, TNF, TP53, and VEGFA were high, and it was speculated that these targets may be key targets of TBFS in the treatment of COPD. The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.