SMAD2 and Myocardial fibrosis: This is manifested that LGQHD can reduce the expression of Ang II and AT1 receptors, down-regulate the expression of TGF-β1 in cardiomyocytes, inhibit Smad2/3 expression, reduce Smad2/3 hyperphosphorylation, and negatively regulate the biological effect of TGF-β1 on myocardial fibrosis, and thus ameliorating myocardial fibrosis.