The top 6 nodes in the interaction network were AKT1 (26), VEGFA (25), NOS3 (24), PPARG (22), MMP9 (22), and VCAM1 (20), (Table 2, Figure 2(b)), which may play an important role in the treatment of T2DM with RS. This evidence concerns the gene NOS3 and type 2 diabetes mellitus.