The patient, at this point, met the 2012 Systemic Lupus Collaborating Clinics (SLICC) criteria (neurologic involvement, positive ANA-IF, anti-dsDNA, and low complement) but was one point short of meeting the cut-off for the 2019 European League Against Rheumatism/American College of Rheumatology (ACR/EULAR) classification criteria (nine points) for SLE. This evidence concerns the gene BTG3 and systemic lupus erythematosus.