In addition, in vivo assay related to the effects of miR-545-3p depletion, circ_0000376 overexpression, or PDPK1 depletion on tumor growth can further validate the regulatory effects of the circ_0000376/miR-545-3p/PDPK1 axis on NSCLC cell phenotypes. Here, PDPK1 is linked to neoplasm.