NLRP3 and atrial fibrillation: They found that colchicine regulates ion channel gene expression and activates the PI3K/AKT/eNOS signaling pathway in rabbits with heart failure, which may reverse atrial remodeling and suppress AF [10]. Yao et al. found NLRP3 inflammasome activity contributing to increased premature atrial contractions and atrial fibrillation [11].