Inhibition of H19 downregulates the expressions of several multidrug resistance genes such as MDR1, MRP1, and ATP-binding cassette super-family G member 2 (ABCG2) in TMZ-resistant cells at the mRNA and protein levels, which suggests H19 plays an important role in the induction of TMZ resistance in glioma cells (Jiang et al. 2016). This evidence concerns the gene ABCB1 and glioma.