H19 and central nervous system cancer: Inhibition of H19 downregulates the expressions of several multidrug resistance genes such as MDR1, MRP1, and ATP-binding cassette super-family G member 2 (ABCG2) in TMZ-resistant cells at the mRNA and protein levels, which suggests H19 plays an important role in the induction of TMZ resistance in glioma cells (Jiang et al. 2016).