IDH is an essential enzyme involved in major metabolic processes such as the TCA cycle, glutamine metabolism, adipogenesis, and redox regulation and has three isoforms, and IDH1 and IDH2 are used as glioma biomarkers (Koh et al. 2004; Lee et al. 2004; Yan et al. 2009). The gene discussed is IDH2; the disease is central nervous system cancer.