Possible explanations include (a) relatively small number (n = 14) of patients in this group, (b) less than optimum performance status of patients treated in routine daily practice, (c) difference in tumour biology which unfortunately cannot be confirmed as the majority of these tumours were not analysed for more modern biological markers such as BRAF, Microsatellite Instability (MSI) and Her2, and (d) differences in third and subsequent lines of therapy which we are unable to confirm as this information was not required when the study was designed. This evidence concerns the gene BRAF and neoplasm.