The phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/Akt) signaling pathway plays an important role in cellular proliferation, cancer, and apoptosis PI3K activation phosphorylates and further activates Akt, promotes FOXO and Bim expression, and leads to cell apoptosis or division [50, 51]. The gene discussed is BCL2L11; the disease is cancer.