The expressions of AR, ATF3, EIF2S1, and mRNA were significantly downregulated in the IDD group, and the expressions of AKR1C3, NQO1, and TXNIP mRNA were significantly upregulated in the IDD group (p value < 0.05; Figures 8(f)–8(k)) which were consistent with the results of database analyses. Here, ATF3 is linked to intervertebral disk degenerative disorder.