In order to implement such intervention strategies effectively, it is crucial to characterize the potential impact of parental family history of AD (FH) and carrying the apolipoprotein ε4 allele (APOE ε4), two major risk factors for AD which are associated with more rapid cognitive decline and earlier age of onset of AD (Martinez et al., 1998), on brain pathology. This evidence concerns the gene APOE and Alzheimer disease.