For instance, they can reduce APP and the deposition of SPs in the brain (Yang et al., 2019), enhance glucose metabolism in AD mice hippocampus (Cao et al., 2017), inhibit synaptic degeneration and neuroinflammation (Cai et al., 2019), promote nerve regeneration and synaptogenesis (Zhao et al., 2020), inhibit neuronal apoptosis, and promote a neuroprotective effect (Tang et al., 2020). This evidence concerns the gene APP and Alzheimer disease.