UNC13A and amyotrophic lateral sclerosis: In this scenario, we combined genotype data of rs12608932 and a broad variety of clinical variables, including age and site of onset, survival, upper (UMN) and lower motor neuron (LMN) signs, functional status, disease progression, cognitive dysfunction and behavioral symptoms within a large cohort of 972 Italian ALS patients, to explore the contribution of the UNC13A locus to ALS phenotypic variability.