Subsequent replication studies and colocalization analyses across neurodegenerative diseases have not only confirmed the association of this locus with ALS susceptibility (van Rheenen et al., 2016), but also revealed that UNC13A is a shared susceptibility locus for ALS and FTD (van Rheenen et al., 2016; Karch et al., 2018), especially in presence of TDP-43 proteinopathy (Diekstra et al., 2014). This evidence concerns the gene UNC13A and amyotrophic lateral sclerosis.