ALDH2 and early-onset autosomal dominant Alzheimer disease: Joshi et al. (2019) suggested such a concept that both ALDH2 inactivating mutation and chronic excessive ethanol intake are potential contributors to Alzheimer’s disease progression. After 11 weeks-intake of ethanol, amyloid β42 levels in the brain were higher in ALDH2*2 mice, compared to the control mice. However, even in the absence of ethanol exposure, Aldh2−/− mice showed an increased hydroxynonenal level and developed Alzheimer’s disease-like pathology (D’Souza et al., 2015).