Few recent studies proposed the association of monocyte chemoattractants, neutrophil activation signature, and pro-apoptotic factors with COVID-19 severity [11,12], and found alterations in biochemical parameters like urea, creatinine, and cystatin C (Cys C) concentrations in severe COVID-19 patients that were significantly higher than those in mild COVID-19 patients [13]. The gene discussed is CST3; the disease is COVID-19.