In this study, we investigated the serum high sensitive C Reactive protein (hs-CRP), ferritin, interleukin-6 (IL-6), lactate dehydrogenase (LDH), and liver enzymes in an intensive care unit (ICU) and non-ICU COVID-19 patients to determine the correlation between these parameters and the severity of COVID-19. This evidence concerns the gene CRP and COVID-19.