We undertook a systematic search through PubMed Central in November 2020 using keywords such as HF, beta-blockers, diuretics, ACE inhibitors, aldosterone antagonists, G-protein-coupled receptor antagonists, digoxin, wet and cold patients, catecholamines, phosphodiesterase inhibitors, calcium sensitizers, action cardiac therapy improving outcome network (ACTION). This evidence concerns the gene ACE and hydrops fetalis.