IKZF1 and CD4+/CD56+ hematodermic neoplasm: In addition, mutations in a number of other genes, including RAS family genes (KRAS, NRAS, etc.), IKAROS family genes (IKZF1, IKZF2, IKZF3, etc.), ABL1, JAK2, FLT3, and NPM1 have also been reported in a subset of BPDCN cases.