Myeloproliferative neoplasms (MPN) result from constitutive activation of the janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway and are characterized by proliferation of differentiated myeloid cells, constitutional and other disease‐related symptoms, increased risk for thrombotic and hemorrhagic events, and a propensity to transform to acute myeloid leukemia. The gene discussed is SOAT1; the disease is myeloproliferative neoplasm.