CUBN and monoclonal gammopathy: In our study, seven patients with monoclonal gammopathy also had elevated levels of one or all three immunoglobulins (Igs) (IgG, IgA, or IgM), one with monoclonal gammopathy had normal levels of Igs, and four with elevated levels of IgG, IgA, or IgM had an absence of monoclonal gammopathy (Table 2).