This research elaborated that APN and amylin were linked with 25-(OH) D, β-CTX, and t-PINP, illuminating that aberrant serum APN and amylin in POP patients were associated with bone metabolism disorders and furthertestifying that blood lipid metabolism disorders and abnormal insulin secretion were linked with the occurrence of POP. The gene discussed is ANPEP; the disease is metabolic bone disorder.