GSTM1 and HOMA-IR: Table 2 shows the demographic, clinical, and laboratory parameters for patients in these two groups. There were significant increases in BMI, ALT/AST, GGT, Homa-IR, APRI, ferritin, Hb, and TBIL in the NAS 5 group, relative to the NAS<5 group. In contrast, HDL-c, Cu, and CP levels were significantly lower in the NAS 5 group relative to the NAS<5 group. The multivariable logistic regression analysis results are shown in Table 3, revealing that ALT/AST, ferritin, and CP were all independently associated with NASH.