Using the RP-LCA smMIPs panel, we sequenced all exonic regions of the genes associated with RP and LCA and, additionally, the intronic regions of the RPE65, all previously published DIVs in RP/LCA genes, as well as the RP17 locus associated with RP ad in 1,192 probands. The gene discussed is CA4; the disease is Leber congenital amaurosis.