In mouse PASMC, 24-hour incubation with 50 μM BI-749327 also inhibits platelet-derived growth factor (PDGF)-mediated phosphorylation of mammalian target of rapamycin (mTOR) and AKT, suggesting that TRPC6 targeting may be a useful avenue for addressing vascular cell hyperproliferation and the decline in right ventricular function in PAH (Jain et al., 2021). This evidence concerns the gene MTOR and pulmonary arterial hypertension.