In MCT-PAH, the RV demonstrates ischemia (due to capillary rarefaction and reduced epicardial perfusion pressure in the right coronary artery) (Tian et al., 2020b) and has increased expression of the glutamine transporter SLC1A5 relative to the pulmonary artery-banded rat model, despite similar severity of RVH (Piao et al., 2013a). Here, SLC1A5 is linked to pulmonary arterial hypertension.