KCNA5 and pulmonary arterial hypertension: O2-sensitive Kv channels, such as Kv1.5, are downregulated in PASMC, both in preclinical PAH models (Michelakis et al., 2001; Bonnet et al., 2006) and in PASMC isolated from PAH patients (Yuan et al., 1998) due, in part, to upregulation of miR-22b, miR-138 and miR-222 (Babicheva et al., 2020).