Stimulation with PDGF, a mitogen that is upregulated in PAH, also leads to serine-896 GluN1 phosphorylation and enhanced cell proliferation in the chronic hypoxia model of PAH, and this is attenuated by the selective NMDAR blockers MK-801 and memantine (Dumas et al., 2018). This evidence concerns the gene GRIN1 and pulmonary arterial hypertension.