Using a collagen-induced arthritis mouse model, Wu et al. reported that the combination of imidazole ketone erastin (a ferroptosis inducer) and etanercept (a tumor necrosis factor (TNF) inhibitor) could induce ferroptotic cell death and inhibit cell proliferation in synovial fibroblasts, thereby attenuating the RA development (Wu et al., 2022). This evidence concerns the gene TNF and arthritic joint disease.