The ASD risk gene Contactin-associated protein-like 2 (Cntnap2/CASPR2), first shown to be altered in patients presenting with severe autism features (Strauss et al., 2006), is a transmembrane scaffolding protein and a cell adhesion protein of the neurexin family which coordinates several processes that are critical for the maturation of neuronal circuits (Benamer et al., 2020), including myelination (Scott et al., 2017), cell excitability (Poliak et al., 1999) and synapse development (Varea et al., 2015). The gene discussed is CNTNAP2; the disease is autism.