OGG1 inhibitors have been shown to dampen cytokines expression in cancer cells and other models, therefore reducing inflammatory responses (Visnes et al., 2018a; Xia et al., 2022; Hajnády et al., 2022), specifically arrest cancer cell proliferation (Visnes et al., 2020) and to enhance methotrexate effect on cancer cells through telomeres instability (Baquero et al., 2021). The gene discussed is OGG1; the disease is cancer.