TLR4 and infection: Separate infection experiments with an Opa− gonococcal strain in murine cells in vitro, and TLR-4 deficient murine lymph node cells with wild-type gonococci, demonstrated reduced levels of IL-10 expression, suggesting a likely role for Opa and the LOS-TLR-4 interaction in this response; although these findings remain to be confirmed in vivo.