As a consequence, the relative mRNA expression ratios of ACE1/ACE2 in either the ROP+ACEi group (1.48-fold ± 0.15) (P = 0.0017) or the ROP+ARNi group (1.39-fold ± 0.11) (P = 0.0023) were significantly higher than in the ROP-Ctrl group (0.77-fold ± 0.09) (Figure 4B). The gene discussed is ACE2; the disease is retinopathy of prematurity.