Besides, ACE2 mRNA expression levels were significantly higher in the ROP+ARNi group (1.91-fold ± 0.36) compared with the SHAM group (1.00-fold ± 0.20) (P = 0.0373) and the ROP-Ctrl group (P = 0.0143). Here, ACE2 is linked to retinopathy of prematurity.