Nrf2/HO-1 axis activation and subsequent attenuation of oxidative stress strongly suppressed inflammation and downregulated intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and inflammatory nitric oxide synthase (iNOS) in a mouse model of diabetic nephropathy [110]. The gene discussed is HMOX1; the disease is diabetic kidney disease.