IL4 and myeloid sarcoma: Relevantly, in the same line of research, using IL-4-induced alternative activated bone marrow-derived macrophages, with immunosuppressive functions, Michal Schwartz’s lab also demonstrated that these macrophages had a suppressive effect on the EAE-associated clinical features that were not observed in the non-injected EAE mice, thus corroborating the protective role of M2-like macrophages in MS-based models, and overall confirming the major contribution of different peripheral cells and phenotypes to either MS onset, progression, and recovery (Vaknin et al., 2011).