Remarkably, the first work about DNA methylation changes in MS patients was published by the group of Patrizia Casaccia (Huynh et al., 2014) and a relevant report of Jagodic’s group identified a differentially methylated region in HLA-DRB1 and a protective variant (rs9267649) that was associated with increased DNA methylation and lower HLA-DRB1 expression in MS (Kular et al., 2018). This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.