We could not demonstrate unambiguously presence of basal laminar deposits that arereported in several animal models (5XFAD, Efemp1R345W/R345W, Sod2knock-down, neprilysin-/-, mcd/mcd, ApoE4 TR, APO*E3 Leiden, APOB100, CEP-immunized and SAMP8 mice) as well as in the eyes of AMD patients [27,28]. The gene discussed is APOE; the disease is age-related macular degeneration.